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serum creatinine > 1.5 mg/dL (132.6 ųmol/L) obtained within the previous 2 monthsħ. hypoglycaemia requiring third party assistance in last 3 months with concomitant glucose 45 kg/m 2Ħ. history of hypoglycaemic coma/seizure within last 12 monthsĢ.
DA PAINA 95.9 TRIAL
In addition, all participants must be eligible for either the blood pressure trial or the lipid trialġ. presence of ≥ 2 of the following factors that increase cardiovascular disease risk: LDL-cholesterol > 130 mg/dL (1 mg/dL = 0.02586 mmol/L) treated with lipid-lowering medication or untreated, low HDL-cholesterol ( 140 mmHg or diastolic blood pressure > 95 mmHg treated with blood pressure-lowering medication or untreated, current cigarette smoking, or BMI > 32 kg/m 2Ħ. if no clinical cardiovascular disease, evidence in the past 2 years suggesting high likelihood of cardiovascular disease (1 risk factor: microalbuminuria, ankle‐brachial index 50% stenosis of a coronary, carotid, or lower extremity artery), orĬ. presence of clinical cardiovascular disease (prior myocardial infarction, stroke, arterial revascularization, angina with ischaemic changes on electrocardiogram at rest, changes on a graded exercise test, or positive cardiac imaging test results)ī. at high risk for cardiovascular disease events, defined asĪ. 55‐79 years (inclusive) for anyone without a history of clinical cardiovascular disease (the age eligibility was modified on the basis of the results of the vanguard phase, so some participants were aged ≥ 80 years at randomisation)ĥ. 40‐79 years (inclusive) for anyone with a history of clinical cardiovascular disease, orī.
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HbA1c level (obtained 1 U/kg and 0 oral anti‐diabetic agents, or (iii) If not on insulin and on 3 oral anti‐diabetic agentsģ. Type 2 diabetes mellitus defined according to the 1997 ADA criteria for ≥ 3 monthsĢ. 2 x 2 factorial randomised clinical trialġ.